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Diagnostic Criteria for NF-1

Two or more of the following: *

  1. Six or more café-au-lait spots 1.5 cm or larger in post-pubertal individuals, 0.5 cm or larger in pre-pubertal individuals
  2. Two or more neurofibromas of any type or one or more plexiform neurofibroma
  3. Freckling in the axilla or groin
  4. Optic glioma (tumor of the optic pathway)
  5. Two or more Lisch nodules (benign iris hamartomas)
  6. A distinctive bony lesion: dysplasia of the sphenoid bone or dysplasia or thinning of long bone cortex
  7. A first-degree relative with NF1

*Click an underlined symptom to view its illustration (image will appear in a new browser window). Images provided by the Harvard Medical School Center for Neurofibromatosis and Allied Disorders.

Effects of NF-1

Neurofibromatosis type 1 (NF-1) is an autosomal dominant genetic disorder that causes tumors to grow on the covering of the nerves anywhere in the body at any time. The disorder affects 1 in 3,000 males and females of all races and ethnic groups. The NF-1 gene is located on chromosome 17.
 
  Neurofibromatosis, Inc.
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  Chicago, IL 60666		 Phone: 630-627-1115
1- 800-942-6825  
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